Author

Shaifaly Parmar

National Cancer InstituteORCID 0000-0002-3960-4405Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Approach:deep learning· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1 Assay:structural biology· 1

Frequent Co-Authors

Desta Doro BumeiD· 2 shared John S. SchneeklothiD· 2 shared Peri R. PrestwoodiD· 2 shared Adeline Feri· 1 shared Colleen M. ConnellyiD· 1 shared Henning Labuhn· 1 shared Jimmy OuelletiD· 1 shared Krishshanthi Sinnadurai· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersBiochemistry

Desta Doro BumeORCID

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintOct 10, 2025

Discovery of small molecule probes targeting the 5' stem-loop in the yeast U4/U6 snRNA

Mo Yang, Shaifaly Parmar, Sumirtha Balaratnam…·John S. Schneekloth

This paper identifies small molecule ligands targeting the K-turn region of the yeast U4/U6 snRNA using a structure-based screening approach and validates their binding effects.

DOI 10.1101/2025.10.10.681657

yeastCITE-seq

𝕏 PostBluesky

BiochemistryNature CommunicationsPeer-reviewedSep 17, 2024

Mechanistic Analysis of Riboswitch Ligand Interactions Provides Insights into Pharmacological Control over Gene Expression

Shaifaly Parmar, Desta Doro Bume, Colleen M. Connelly…·John S. Schneekloth

This study investigates how different small molecules affect riboswitch activity by altering RNA conformation, showing distinct mechanisms in live cells.

15 citations

structural biologyproteomics

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