A chemoinformatics-guided platform for efficient discovery of RNA-binding small molecules: Proof-of-concept for myotonic dystrophy type 1
Amirhossein Taghavi, Jingsong Shan, Xiyuan Yao, Patrick R. A. Zanon, Kisu Sung, Álvaro Simba-Lahuasi, Sylwia Gorlach, Henning Labuhn, David Georges Salthouse, Zhen Wang, Adeline Feri, Matthew David Disney
The paper develops a chemoinformatics platform to discover RNA-binding small molecules, identifying ligands for the r(CUG)exp RNA in DM1 with splicing rescue activity.
bioRxiv · May 13, 2026 · PreprintBioinformatics