Peri R. Prestwood

This paper identifies small molecule ligands targeting the K-turn region of the yeast U4/U6 snRNA using a structure-based screening approach and validates their binding effects.

The paper uses machine learning-augmented MD simulations to study ZTP riboswitch ligand interactions, finding that ligand on-rates, not binding affinity, determine activation potency.

This study investigates how different small molecules affect riboswitch activity by altering RNA conformation, showing distinct mechanisms in live cells.