The paper investigates how N6-methyladenosine (m6A) regulates different histone H1 subtypes, identifying m6A readers and proposing a model for subtype-specific regulation.

bioRxiv · Jan 22, 2025 · PreprintMolecular Biology

Antimicrobial and antibiofilm activity of human recombinant H1 histones against bacterial infections

Betsy Verónica Arévalo‐Jaimes, Mónica Salinas‐Pena, Inma Ponte, Albert Jordan, Alicia Roque, Eduard Torrents

This study evaluates the antimicrobial and antibiofilm activity of human recombinant H1 histones against Pseudomonas aeruginosa, showing efficacy and safety in vitro and in vivo.

mSystems · Oct 29, 2024Peer-reviewedMicrobiology

Histone H1 regulates non-coding RNA turnover on chromatin in a m6A-dependent manner

José Miguel Fernández-Justel, Cristina Santa-María, Sara Martín-Vírgala, Shreya Ramesh, Alberto Ferrera-Lagoa, Mónica Salinas‐Pena, Javier Isoler‐Alcaráz, Magdalena M. Maslon, Albert Jordan, Javier F. Cáceres, Marı́a Gómez

This study shows histone H1 regulates non-coding RNA turnover on chromatin through m6A modification, affecting replication-transcription conflicts.

Cell Reports · Sep 1, 2022Peer-reviewedMolecular Biology

Coordinated changes in gene expression, H1 variant distribution and genome 3D conformation in response to H1 depletion

Núria Serna‐Pujol, Mónica Salinas‐Pena, Francesca Mugianesi, François Le Dily, Marc A. Martı́-Renom, Albert Jordan

The paper investigates how H1 depletion affects gene expression, H1 variant distribution, and genome 3D conformation in breast cancer cells.

Nucleic Acids Research · Mar 28, 2022Peer-reviewedGenomics

Towards understanding the regulation of histone H1 somatic subtypes with OMICs.

Inma Ponte, Marta Andrés, Albert Jordan, Alicia Roque

The paper investigates the regulation of histone H1 somatic subtypes using integrated OMICs data, finding that transcriptional control and co-regulation explain variability in H1 complement and subtype dynamics.

Journal of Molecular Biology · Dec 3, 2020Peer-reviewedMolecular Biology