This study identifies YTHDC1 as a master regulator of the p53 response through m6A-dependent and -independent mechanisms that affect transcriptional elongation and genomic stability.

The EMBO Journal · Jul 1, 2024Peer-reviewedCancer Biology

Histone H1 regulates non-coding RNA turnover on chromatin in a m6A-dependent manner

José Miguel Fernández-Justel, Cristina Santa-María, Sara Martín-Vírgala, Shreya Ramesh, Alberto Ferrera-Lagoa, Mónica Salinas‐Pena, Javier Isoler‐Alcaráz, Magdalena M. Maslon, Albert Jordan, Javier F. Cáceres, Marı́a Gómez

This study shows histone H1 regulates non-coding RNA turnover on chromatin through m6A modification, affecting replication-transcription conflicts.

Cell Reports · Sep 1, 2022Peer-reviewedMolecular Biology

Three-dimensional connectivity and chromatin environment mediate the activation efficiency of mammalian DNA replication origins

Karolina Jodkowska, Véra Pancaldi, Ricardo Almeida, Maria Rigau, Osvaldo Graña‐Castro, José Miguel Fernández-Justel, Sara Rodríguez‐Acebes, Miriam Rubio-Camarillo, Enrique Carrillo de Santa Pau, David G. Pisano, Fátima Al‐Shahrour, Alfonso María Valencia, Marı́a Gómez, Juan Méndez

The paper investigates how 3D chromatin structure and chromatin environment influence DNA replication origin activation efficiency in mouse embryonic stem cells under stress and control conditions.

bioRxiv · May 29, 2019 · PreprintGenomics