Lee‐Wei Yang

The paper investigates the roles of core promoter elements -35 and -10 in Escherichia coli, showing -10 is essential for promoter evolution while -35 influences gene regulation through interactions with transcription factors.

This paper identifies FDA-approved drugs that modulate SARS-CoV-2 -1 PRF by altering RNA pseudoknot folding dynamics, demonstrating a strategy for targeting structured RNAs.

This study uses time-dependent linear response theory to identify allosteric sites in enzymes, finding that mutations at these sites significantly affect enzyme activity and that certain drugs inhibit these sites with therapeutic effects.

The paper introduces TP-DB, a database of helical peptides with pattern-based search capabilities, demonstrating its utility in designing therapeutic peptides and diagnostic tools for pathogens.

DRDOCK automates drug repurposing by integrating docking, MD simulations, and a log-odds ranking system to identify potential drug candidates for new diseases.

The paper introduces two filters, DR and SIP, to improve quaternary structure prediction for transmembrane proteins using distance restraints and cyclic symmetry.