Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy
Vincent Rondeau, Suraj Bansal, Marco M. Buttigieg, Andy G.X. Zeng, Darryl Y. Chan, Michelle Chan‐Seng‐Yue, Jin Liqing, Jessica L. McLeod, Meghan Kates, Elisa Donato, Patrick Stelmach, Caitlyn Vlasschaert, Yitong Yang, Aarushi Gupta, Sofia Genta, , Robert J. Vanner
This study shows that hematopoietic Tet2 inactivation improves immune checkpoint blockade response in mice and is associated with better clinical outcomes in melanoma patients with TET2-driven clonal hematopoiesis.
Cancer Research · Nov 11, 2025Peer-reviewedCancer Biology