PhysiologyiSciencePeer-reviewed
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APOE4 drives widespread changes to the hepatic proteome and alters metabolic function
Colton R Lysaker, Chelsea N. Johnson, Vivien Csikós…·Heather Wilkins
In 4-month-old APOE targeted-replacement mice, APOE4 remodels the liver proteome sex-dependently; in isogenic iPSC-derived hepatocytes it impairs respiration and raises glycolysis and lipid droplets.