The gut-liver axis and the role of bacteria in severe dengue virus infection in mice
Adriana C. Pliego Zamora, Jae Hyeon Kim, Naphak Modhiran, Karli Takizawa, Ennae Gollasch-Miller, Ran Wang, Paul R. Young, Daniel Watterson, Sumaira Zia Hasnain, Parimala R. Vajjhala, Yuji Sekiguchi, Helle Bielefeldt‐Ohmann, Dieter M. Tourlousse, Katryn J. Stacey
This study shows that DENV infection in mice causes gut barrier damage, bacterial translocation, and dysbiosis, which contribute to liver inflammation and disease severity.
bioRxiv · Sep 23, 2026 · PreprintMicrobiology