ImmunologyProceedings of the National Academy of SciencesPeer-reviewed
MDA5 ISGylation is crucial for immune signaling to control viral replication and pathogenesis
Lucky Sarkar, Guanqun Liu, Dhiraj Acharya…·Michaela U. Gack
This study shows that MDA5 ISGylation is essential for antiviral immunity, as its disruption leads to impaired cytokine responses and increased viral replication in mice.
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