Michaela Ulrike Gack

This study shows HOIL1 ubiquitinates LGP2 to activate MDA5 and induce IFN responses, highlighting a mechanism distinct from RIG-I sensing.

This study identifies Nsp3-mediated dephosphorylation of the N protein by PP1/gamma as essential for SARS-CoV-2 subgenomic RNA synthesis.

This study shows HSV infection increases ALS risk and promotes TDP-43 pathology through ICP0-mediated disruption of PML bodies.

This study shows that SARS-CoV-2 deISGylation by PLpro suppresses innate immunity and promotes viral replication by modulating cellular metabolism.

The paper identifies TRIM32 as an antiviral protein that inhibits SARS-CoV-2 replication by SUMOylating NSP14, thereby blocking its exonuclease activity.

This study shows that MDA5 ISGylation is essential for antiviral immunity, as its disruption leads to impaired cytokine responses and increased viral replication in mice.

This study identifies ISGylation of SARS-CoV-2 N protein by HERC5 as a host restriction factor that inhibits viral RNA synthesis by blocking N oligomerization.

The paper introduces FD-seq, a method for single-cell RNA sequencing of fixed cells, and applies it to study virus infection and host response in rare cell populations.

The paper examines sex differences in COVID-19 outcomes and immune responses using single-cell RNA-sequencing and clinical data, finding higher risk for males and potential mechanisms for sex-specific treatments.