Junji Zhu

This study shows HOIL1 ubiquitinates LGP2 to activate MDA5 and induce IFN responses, highlighting a mechanism distinct from RIG-I sensing.

This study identifies Nsp3-mediated dephosphorylation of the N protein by PP1/gamma as essential for SARS-CoV-2 subgenomic RNA synthesis.

This study shows that SARS-CoV-2 deISGylation by PLpro suppresses innate immunity and promotes viral replication by modulating cellular metabolism.

This study shows that MDA5 ISGylation is essential for antiviral immunity, as its disruption leads to impaired cytokine responses and increased viral replication in mice.

This study identifies ISGylation of SARS-CoV-2 N protein by HERC5 as a host restriction factor that inhibits viral RNA synthesis by blocking N oligomerization.