Author
Cleveland ClinicORCID 0000-0003-1799-7604Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Junji Zhu, Guanqun Liu, Jielin Xu…·Michaela Ulrike Gack
This study shows that SARS-CoV-2 deISGylation by PLpro suppresses innate immunity and promotes viral replication by modulating cellular metabolism.
Lucky Sarkar, Guanqun Liu, Dhiraj Acharya…·Michaela U. Gack
This study shows that MDA5 ISGylation is essential for antiviral immunity, as its disruption leads to impaired cytokine responses and increased viral replication in mice.
Junji Zhu, Guanqun Liu, Zuberwasim Sayyad…·Michaela U. Gack
This study identifies ISGylation of SARS-CoV-2 N protein by HERC5 as a host restriction factor that inhibits viral RNA synthesis by blocking N oligomerization.