A brain-penetrant P2X7R antagonist mitigates Alzheimer's disease pathology
Andreea L. Turcu, Adam C. Oken, Christian Griñán‐Ferré, Anna Durner, Juan Sierra‐Marquez, Sonja Hinz-Kowalik, Jessica Nagel, So‐Deok Lee, Eva Tzortzini, Kyriakos Georgiou, Mamina Bhol, Zuriñe Baz, Jordi Llop, Marion Schneider, Carla Barbaraci, , Santiago Vázquez
This paper identifies UB-ALT-P2, a P2X7R antagonist that reduces Alzheimer's disease pathology in mice by improving memory, reducing amyloid-beta and tau, and decreasing inflammation.
bioRxiv · Apr 9, 2026 · PreprintNeuroscience