Author

So‐Deok Lee

Gwangju Institute of Science and Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:cryo-EM· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Adam C. OkeniD· 2 shared Andreea L. TurcuiD· 2 shared Annette NickeiD· 2 shared Antonios KolocourisiD· 2 shared Christa Elisabeth MülleriD· 2 shared Eva TzortziniiD· 2 shared Garam KimiD· 2 shared Jessica NageliD· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersNeuroscience

Adam C. OkenORCID

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2 papers

Recent·Most cited

A brain-penetrant P2X7R antagonist mitigates Alzheimer's disease pathology

Andreea L. Turcu, Adam C. Oken, Christian Griñán‐Ferré, Anna Durner, Juan Sierra‐Marquez, Sonja Hinz-Kowalik, Jessica Nagel, So‐Deok Lee, Eva Tzortzini, Kyriakos Georgiou, Mamina Bhol, Zuriñe Baz, Jordi Llop, Marion Schneider, Carla Barbaraci, , Santiago Vázquez

This paper identifies UB-ALT-P2, a P2X7R antagonist that reduces Alzheimer's disease pathology in mice by improving memory, reducing amyloid-beta and tau, and decreasing inflammation.

bioRxiv · Apr 9, 2026 · PreprintNeuroscience

UB-MBX-46 is a potent and selective antagonist of the human P2X7 receptor developed by structure-based drug design

Adam C. Oken, Andreea L. Turcu, Eva Tzortzini, Kyriakos Georgiou, Jessica Nagel, Marta Barniol‐Xicota, Garam Kim, So‐Deok Lee, Annette Nicke, Yong‐Chul Kim, Christa Elisabeth Müller, Antonios Kolocouris, Santiago Vázquez, Steven Mansoor

The paper identifies molecular features of the human P2X7 receptor using cryo-EM structures and designs a potent, selective antagonist, UB-MBX-46, with picomolar potency and high selectivity.

bioRxiv · Feb 12, 2025 · PreprintBiochemistry