Sandra J. Shefelbine

This paper introduces a computational framework to model limb skeletal patterning in mice and axolotls by integrating growth, gene regulation, and signaling spread, showing varying contributions of these factors across limb regions.

The paper investigates the role of TRPV4 and PIEZO2 in axolotl limb regeneration, finding that TRPV4 inhibition reduces limb length without affecting cartilage differentiation.

This study examines how mechanical loading and Piezo1 activation affect bone adaptation in aged mice, finding an additive effect on cortical bone parameters.

This study uses WISH-BONE to analyze 3D Sost mRNA and sclerostin distribution in mouse tibia midshafts after mechanical loading, showing region-specific changes and highlighting the method's importance for mechanoadaptation research.

WISH-BONE labels osteocyte mRNA and protein in 3D adult mouse bones, enabling spatially preserved biomarker expression analysis.

This study investigates Turing pattern formation in 3D domains, showing that initial conditions and domain growth influence pattern stability and emergence.

The paper investigates how mechanical stimuli influence joint morphogenesis by combining experimental and computational approaches in axolotl limb regeneration.

This paper develops a method to visualize and quantify macromolecule synthesis in vivo using click chemistry and light sheet microscopy, demonstrating its sensitivity to biological perturbations.