Luisa Speranza

Maternal separation remodels Purkinje cell circuits and impairs cerebellar synaptic plasticity

This study shows that maternal separation alters cerebellar circuitry and synaptic plasticity, leading to behavioral and neurobiological deficits in mice.

Combined DiI and antibody labeling reveals complex dysgenesis of hippocampal spine synapses in a mouse model of Fragile X Syndrome.

The paper introduces an optimized methodology combining DiI and immunofluorescence to study hippocampal spine synapses in Fmr1 KO mice, revealing structural abnormalities associated with Fragile X Syndrome.

Stabilization of spine Synaptopodin by mGluR1 is required for mGluR-LTD

The paper shows that mGluR1 stabilizes Synaptopodin in spines to enable mGluR-LTD, preserving spines with Synaptopodin/SA while eliminating others.

The G protein-Coupled Metabotropic Glutamate Receptor 1 controls neuronal macroautophagy

This study identifies mGlu1 receptor's role in regulating neuronal autophagy and shows FEZ1 mediates this regulation by linking mGlu1 to Ulk1.