Anna Francesconi

This study identifies 7 nAChR hypofunction as a therapeutic target in FXS by showing that restoring 7 nAChR function improves behavioral deficits in Fmr1KO mice.

This study shows that loss of synaptopodin impairs mGluR5-dependent mGluR-LTD at CA3-CA1 synapses, leading to protein synthesis-independent LTD mediated by endocannabinoid signaling.

The paper introduces an optimized methodology combining DiI and immunofluorescence to study hippocampal spine synapses in Fmr1 KO mice, revealing structural abnormalities associated with Fragile X Syndrome.

The paper shows that mGluR1 stabilizes Synaptopodin in spines to enable mGluR-LTD, preserving spines with Synaptopodin/SA while eliminating others.

This study identifies mGlu1 receptor's role in regulating neuronal autophagy and shows FEZ1 mediates this regulation by linking mGlu1 to Ulk1.