Author

Pei You Wu

McGill UniversityORCID 0000-0002-9732-4663Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4

Frequent Co-Authors

Rebecca Anne McKinneyiD· 3 shared Yanis InglebertiD· 3 shared Anna FrancesconiiD· 2 shared Claudia De SanctisiD· 2 shared Cong Loc DangiD· 1 shared David ColameoiD· 1 shared Fanny Sandrine MartineauiD· 1 shared Jan KlohsiD· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersNeuroscience

Rebecca Anne McKinneyORCID

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4 papers

Recent·Most cited

Synaptopodin is required for long-term depression at Schaffer collateral-CA1 synapses

Yanis Inglebert, Pei You Wu, Julia Tourbina-Kolomiets, Cong Loc Dang, Rebecca Anne McKinney

This study shows that synaptopodin is essential for long-term depression at Schaffer collateral-CA1 synapses but not for long-term potentiation.

Molecular Brain · Apr 2, 2024Peer-reviewedNeuroscience

Loss of synaptopodin impairs mGluR5 and protein synthesis dependent mGluR-LTD at CA3-CA1 synapses

Pei You Wu, Linjia Ji, Claudia De Sanctis, Anna Francesconi, Yanis Inglebert, Rebecca Anne McKinney

This study shows that loss of synaptopodin impairs mGluR5-dependent mGluR-LTD at CA3-CA1 synapses, leading to protein synthesis-independent LTD mediated by endocannabinoid signaling.

PNAS Nexus · Feb 1, 2024Peer-reviewedNeuroscience

Blocking gephyrin phosphorylation or microglia BDNF signaling prevents synapse loss and reduces infarct volume after ischemia

Teresa L.M. Cramer, Raminder Gill, Zahra S. Thirouin, Markus Vaas, Suchita Sampath, Fanny Sandrine Martineau, Sara B. Noya, Patrizia Panzanelli, Tania J. J. Sudharshan, David Colameo, Philip K.‐Y. Chang, Pei You Wu, Roy Shi, Philip A. Barker, Steven A. Brown, , Shiva K. Tyagarajan

Science Advances · Mar 4, 2022Peer-reviewedNeuroscience

Stabilization of spine Synaptopodin by mGluR1 is required for mGluR-LTD

Luisa Speranza, Yanis Inglebert, Claudia De Sanctis, Pei You Wu, Magdalena Kalinowska, R. Anne McKinney, Anna Francesconi

The paper shows that mGluR1 stabilizes Synaptopodin in spines to enable mGluR-LTD, preserving spines with Synaptopodin/SA while eliminating others.

Journal of Neuroscience · Jan 19, 2022Peer-reviewedNeuroscience