Cell BiologybioRxivPreprint
Mitochondrial heterogeneity disrupts osteoclast differentiation and bone resorption by impairing respiratory complex I
Houfu Leng, Jiahao Jiang, Katja Gassner…·Anna Katharina Simon
This study shows mitochondrial heteroplasmy impairs osteoclast differentiation and bone resorption by disrupting respiratory complex I and autophagy, and identifies spermidine as a potential therapeutic.