Extrafollicular plasma cells disable dendritic cell-T-cell priming in tumor-draining lymph nodes
Elena Alberts, Victoire Boulat, Miu Shing Hung, An Qi Xu, Jelmar Quist, Mengyuan Li, Fangfang Liu, Isobelle Wall, Gregory E Verghese, Carin Andrea Brundin, Ananya Bhalla, Mats Jönsson, Carlos A. Castellanos, James Rosekilly, Cheryl Gillett, , Dinis Pedro Calado
The paper identifies extrafollicular plasma cells as an antibody-independent checkpoint that inhibits dendritic cell-T-cell priming in tumor-draining lymph nodes, leading to poor prognosis and immune-checkpoint resistance.
bioRxiv · Apr 22, 2026 · PreprintImmunology