Victoire Boulat

The paper shows that immune surveillance in germinal centers eliminates premalignant B-cells, but lymphoma-like mutations allow immune escape and progression to lymphoma.

The paper identifies extrafollicular plasma cells as an antibody-independent checkpoint that inhibits dendritic cell-T-cell priming in tumor-draining lymph nodes, leading to poor prognosis and immune-checkpoint resistance.

This study identifies lactate as a tumor-secreted metabolite that inhibits B cell chemotaxis and TLS formation in TNBC by disrupting mitochondrial metabolism.