Douglas J. Chapski

ER Stress-Response Signaling Regulates Chamber-Specific Growth between Right and Left Ventricles during Postnatal Development.

This study identifies the IRE1-Xbp1-Vimp/Rpn2 axis as a regulator of differential growth between left and right ventricles during postnatal development by modulating cardiomyocyte proliferation, hypertrophy, and apoptosis.

Novel Insights into Post-Myocardial Infarction Cardiac Remodeling through Algorithmic Detection of Cell-Type Composition Shifts

The paper develops an algorithm to correct cell-type composition in bulk RNAseq data, revealing novel gene pathways in post-myocardial infarction cardiac remodeling.

Rapid onset fibrotic remodeling and ventricular dysfunction induced by phenylephrine involve targeted reprogramming of myocyte and fibroblast transcriptomes

This study shows that phenylephrine induces rapid fibrotic remodeling and ventricular dysfunction in mice through myocyte and fibroblast transcriptome reprogramming.

Circadian Control of Histone Turnover During Cardiac Development and Growth

This study shows Bmal1 is essential for neonatal myocyte growth, histone turnover, and chromatin organization, with Sik1 as a novel clock-controlled gene linking myocyte growth to gene transcription.

Decreased Left Atrial Cardiomyocyte FGF13 Expression Increases Vulnerability to Postoperative Atrial Fibrillation in Humans

The paper identifies decreased FGF13 expression in left atrial cardiomyocytes as a factor increasing vulnerability to postoperative atrial fibrillation in humans.

genomeSidekick: a user-friendly epigenomics data analysis tool

genomeSidekick provides a user-friendly tool for analyzing epigenomics data, enabling researchers to perform analyses and visualize results without bioinformatics expertise.