Author

Andrew Scott Liss

Harvard UniversityORCID 0000-0002-4040-9172Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 3 Approach:statistical model· 2 Research Focus:variant calling· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Aaron M. WengeriD· 2 shared Asher BryantiD· 2 shared Ayşe Gökçe KeşküşiD· 2 shared Benedict PateniD· 2 shared Christopher E. MasoniD· 2 shared Chunlin XiaoiD· 2 shared Elizabeth M. Munding· 2 shared Erin CrossiD· 2 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersGenomics

Aaron M. WengerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A near-complete human pancreatic cancer genome

Justin Wagner, Ayşe Gökçe Keşküş, Keisuke K. Oshima, T. Rhyker Ranallo-Benavidez, Jennifer McDaniel, Shu-Cheng Chuang, Mile Šikić, Luis F. Paulin, Adam C. English, Fritz Joachim Sedlazeck, Elizabeth M. Munding, Zack Sanborn, Andrew W. Carroll, Pi-Chuan Chang, Daniel E. Cook, , Justin M. Zook

This paper presents near-complete, haplotype-resolved assemblies of a pancreatic cancer genome and normal tissue, identifying extensive somatic variants and epigenetic changes in previously excluded regions.

bioRxiv · May 10, 2026 · PreprintGenomics

Development and extensive sequencing of a broadly-consented Genome in a Bottle matched tumor-normal pair

Jennifer McDaniel, Vaidehi Patel, Nathan D. Olson, Hua‐Jun He, Zhiyong He, Kenneth D. Cole, Alexander A Gooden, Anthony D. Schmitt, Kristin L Sikkink, Fritz Joachim Sedlazeck, HarshaVardhan Doddapaneni, Shalini N. Jhangiani, Donna Marie Muzny, Marie‐Claude Gingras, Heer Hemant Mehta, , Justin M. Zook

The paper describes a comprehensive genomic dataset from a tumor-normal pair with broad consent, generated using multiple sequencing technologies for benchmarking somatic variant detection.

Scientific Data · Jul 16, 2025Peer-reviewedGenomics

Single-nucleus and spatial transcriptomics of archival pancreatic cancer reveals multi-compartment reprogramming after neoadjuvant treatment

William L. Hwang, Karthik A. Jagadeesh, Jimmy A. Guo, Hannah I. Hoffman, Payman Yadollahpour, Rahul R. Mohan, Eugene Drokhlyansky, Nicholas Van Wittenberghe, Orr Ashenberg, Samouil L. Farhi, Denis Schapiro, Jason Reeves, Daniel R. Zollinger, George M. Eng, Jason M. Schenkel, , Aviv Regev

This study uses single-nucleus and spatial transcriptomics to analyze pancreatic cancer before and after neoadjuvant treatment, revealing changes in cell states and immune infiltration that may inform therapy.

bioRxiv · Aug 25, 2020 · PreprintGenomics