Author

Timothy J. Semple

Peter MacCallum Cancer CentreORCID 0000-0002-4048-1553Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

David YoannidisiD· 2 shared Richard LupatiD· 2 shared Abdelillah MaaradiD· 1 shared Ana Carolina Bastos Sant'Anna SilvaiD· 1 shared Andrew R. GreeniD· 1 shared Ari M. MelnickiD· 1 shared Arnaud JacqueliD· 1 shared Calixte CalaudiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersCancer Biology

David YoannidisORCID

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3 papers

Recent·Most cited

Enhanced efficacy of a specific HDAC3 inhibitor in combination with 5-Azacitidine against diffuse large B-cell lymphoma

Calixte Calaud, Emilio M. Serrano-López, Leonie A. Cluse, Izabela Todorovski, Thomas Mardivirin, Matt R. Teater, Abdelillah Maarad, Noura Tawfic, Peter Fraser, Killian Guiraud, Coralie F Dupont, Corinne Ménigot, Ana Carolina Bastos Sant'Anna Silva, David Yoannidis, Timothy J. Semple, , Pilar M. Domínguez

This study shows that combining a HDAC3 inhibitor with 5-Azacitidine enhances anti-tumor effects against DLBCL in vitro and in vivo, with reduced toxicity compared to single agents.

Blood Neoplasia · Mar 2, 2026Peer-reviewedCancer Biology

Phylogenetic analysis of paired breast carcinomas identifies genetic events associated with clonal recurrence and invasive progression

Tanjina Kader, Maia Zethoven, Sakshi Mahale, Hugo Saunders, Lauren Tjoeka, Rebecca Lehmann, Madawa W Jayawardana, Jia‐Min Pang, Dorothea Lesche, Neeha Rajan, Timothy J. Semple, Jue Er Amanda Lee, Richard Lupat, David J. Byrne, Siobhan Hughes, , Kylie L. Gorringe

The paper analyzes paired breast carcinomas to determine if recurrences are clonal or new tumors, finding 7% are non-clonal by whole exome sequencing.

The Journal of Pathology · Oct 30, 2025Peer-reviewedCancer Biology

macpie: scalable workflow for high-throughput transcriptomic profiling

Nenad Bartoniček, Xin Liu, Laura Twomey, Michelle Meier, Richard Lupat, Stuart Craig, David Yoannidis, Jason Li, Timothy J. Semple, Kaylene J. Simpson, Xiang Li, Susanne Ramm

macpie streamlines analysis of high-throughput transcriptomic profiling data from plate-based screens using R, integrating preprocessing, quality control, and multimodal data integration.

Computational and Structural Biotechnology Journal · Jan 1, 2025Peer-reviewedBioinformatics