Makoto Miyakoshi

Prediction of treatment response in infantile epileptic spasms syndrome using EEG phase-amplitude coupling

The paper predicts treatment response in infantile epileptic spasms syndrome using EEG phase-amplitude coupling, finding that lower pre-treatment modulation index values correlate with better treatment outcomes.

Event-Related Spatio-Spectral Perturbation (ERSSP): A Scalp-Wide EEG Analysis Framework for Capturing Extralemniscal Thalamocortical Activity, Validated Using a Fragile X Syndrome Model

The paper introduces ERSSP, an EEG analysis framework to study extralemniscal thalamocortical activity, validated in Fragile X Syndrome showing increased spatial power increases.

Frontal Cortex Hyperactivation and Gamma Desynchrony in Fragile X Syndrome: Correlates of Auditory Hypersensitivity

This study investigates neural correlates of auditory hypersensitivity in FXS using EEG source analysis, finding frontal cortex hyperactivation and gamma desynchrony linked to auditory processing issues.

An iPSC model of fragile X syndrome reflects clinical phenotypes and reveals m6A-mediated epi-transcriptomic dysregulation underlying synaptic dysfunction

This study uses iPSC-derived neurons to show that FMRP deficiency in fragile X syndrome leads to m6A-mediated transcriptome dysregulation, causing synaptic dysfunction and suggesting therapeutic targets.

Click-train evoked steady-state harmonic response as a novel pharmacodynamic biomarker of cortical oscillatory synchrony

The paper investigates SSHR as a pharmacodynamic biomarker of cortical oscillatory synchrony, showing distinct pharmacological sensitivity compared to ASSR.