Lu Lu

This study uses iPSC-derived neurons to show that FMRP deficiency in fragile X syndrome leads to m6A-mediated transcriptome dysregulation, causing synaptic dysfunction and suggesting therapeutic targets.

This study investigates GABAergic neuron dysfunction in psychiatric disorder models, finding mutation-dependent synaptic deficits and shared gene expression changes in DISC1 mutant neurons.

This study identifies TRPC3 as a therapeutic target for Alzheimer's disease by showing its role in synaptic dysfunction and memory deficits, with JW-65 as a potential inhibitor.