Author

Paul H. Edelstein

MRC Laboratory of Molecular BiologyORCID 0000-0002-4069-5279Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:Bayesian inference· 1 Assay:cryo-EM· 1 Research Focus:GWAS / association mapping· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Lalita RamakrishnaniD· 3 shared Mark A. TrolliD· 3 shared Adam J. FountainiD· 2 shared Ahmad Rizal GaniemiD· 1 shared Arjan van LaarhoveniD· 1 shared Bachti AlisjahbanaiD· 1 shared Ben F. LuisiiD· 1 shared Chen‐Yi CheungiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersMicrobiology

Lalita RamakrishnanORCID

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintJun 24, 2025

Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistance

Adam J. Fountain, Jan Böhning, Stephen H. McLaughlin…·Lalita Ramakrishnan

This study determines the cryo-EM structure of the MmpS5L5 efflux pump in Mycobacterium tuberculosis and identifies mutations that enhance bedaquiline efflux, suggesting new resistance mechanisms.

4 citations

cryo-EMexperimental assay

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MicrobiologybioRxivPreprintFeb 6, 2025

Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to potentiate the activity bedaquiline and other antitubercular drugs

Adam J. Fountain, Natalie J.E. Waller, Chen‐Yi Cheung…·Lalita Ramakrishnan

DOI 10.1101/2025.02.06.636695

humanexperimental assay

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Molecular BiologybioRxivPreprintAug 3, 2020

A Bayesian analysis of the association between Leukotriene A4 Hydrolase genotype and survival probability of tuberculous meningitis patients treated with adjunctive dexamethasone

Laura J. Whitworth, Jacob Coxon, Arjan van Laarhoven…·Lalita Ramakrishnan

The paper uses Bayesian analysis to show the LTA4H TT genotype improves survival in TBM patients in Vietnam and Indonesia, but only when disease severity is not the primary cause of mortality.

1 citation

humanBayesian inference

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