Author

Adam J. Fountain

MRC Laboratory of Molecular BiologyORCID 0000-0003-4232-3791Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Lalita RamakrishnaniD· 2 shared Mark A. TrolliD· 2 shared Paul H. EdelsteiniD· 2 shared Ben F. LuisiiD· 1 shared Chen‐Yi CheungiD· 1 shared Gregory Murray CookiD· 1 shared Jan BöhningiD· 1 shared Matthew B. McNeiliD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMicrobiology

Lalita RamakrishnanORCID

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2 papers

Recent·Most cited

Structural and functional analysis of the Mycobacterium tuberculosis MmpS5L5 efflux pump presages a pathway to increased bedaquiline resistance

Adam J. Fountain, Jan Böhning, Stephen H. McLaughlin, Tomos E. Morgan, Paul H. Edelstein, Mark A. Troll, Meindert Hugo Lamers, Tanmay A. M. Bharat, Ben F. Luisi, Lalita Ramakrishnan

This study determines the cryo-EM structure of the MmpS5L5 efflux pump in Mycobacterium tuberculosis and identifies mutations that enhance bedaquiline efflux, suggesting new resistance mechanisms.

bioRxiv · Jun 24, 2025 · PreprintMicrobiology

Verapamil and its metabolite norverapamil inhibit the Mycobacterium tuberculosis MmpS5L5 efflux pump to potentiate the activity bedaquiline and other antitubercular drugs

Adam J. Fountain, Natalie J.E. Waller, Chen‐Yi Cheung, William J Jowsey, Michael T Chrisp, Mark A. Troll, Paul H. Edelstein, Gregory Murray Cook, Matthew B. McNeil, Lalita Ramakrishnan

bioRxiv · Feb 6, 2025 · PreprintMicrobiology