BiophysicsNature Structural & Molecular BiologyPeer-reviewed
Early intermediates in bacterial RNA polymerase promoter melting visualized by time-resolved cryo-electron microscopy
Ruth M. Saecker, Andreas U. Müller, Brandon F. Malone…·Seth Andrew Darst
This study uses time-resolved cryo-EM to visualize early intermediates in bacterial RNA polymerase promoter melting, revealing key steps in the formation of the transcription-competent open complex.