Jonathan W. Kanen

Computational modeling of reinforcement learning and functional neuroimaging of probabilistic reversal dissociates compulsive behaviors in Gambling and Cocaine Use Disorders

The paper uses reinforcement learning models and fMRI to analyze cognitive flexibility differences in Gambling Disorder and Cocaine Use Disorder, finding distinct neural and behavioral patterns.

Common roles for serotonin in rats and humans for computations underlying flexible decision-making

This study shows that serotonin manipulations affect decision-making flexibility in rats and humans through similar computational mechanisms.

Angiotensin blockade enhances motivational reward learning via enhancing ventral striatal prediction error and frontostriatal communication

This study shows that losartan improves reward learning by enhancing ventral striatal prediction errors and frontostriatal communication in healthy humans.

Effect of lysergic acid diethylamide (LSD) on reinforcement learning in humans

This study investigates how LSD affects reinforcement learning in humans by examining changes in learning rates, reinforcement sensitivity, and exploratory behavior during a probabilistic reversal learning task.

Serotonin depletion impairs both Pavlovian and instrumental reversal learning in healthy humans

This study shows that serotonin depletion impairs reversal learning and emotional updating in humans, correlating with the degree of tryptophan depletion.

Perseverative behavior under uncertainty is enhanced by tryptophan depletion but diminished with subclinical obsessive-compulsive symptoms

The paper was withdrawn due to substantial changes in results and interpretation after further analysis.

Serotonin depletion amplifies distinct human social emotions as a function of individual differences in personality

The paper shows that serotonin depletion enhances emotional responses to social conflict, interacting with personality traits to produce distinct emotions like guilt and annoyance.

Effect of tryptophan depletion on conditioned threat memory expression: role of intolerance of uncertainty

This study examines how tryptophan depletion affects conditioned threat memory and finds that serotonin reduction attenuates emotional memory expression, particularly in individuals with higher intolerance of uncertainty.

Eye-movement intervention enhances extinction via amygdala deactivation

This study shows that eye-movement interventions reduce fear recovery by temporarily deactivating the amygdala during extinction learning, similar to working memory tasks.