Gitte M. Knudsen

The paper describes the OpenNeuroPET initiative, which develops standards and open-source tools to standardize and share PET neuroimaging data, enhancing reproducibility and collaboration.

This study compares CSF-to-brain tracer exchange in pigs under two anesthetic regimens, finding higher tracer accumulation with ketamine/dexmedetomidine compared to propofol.

The paper examines how diurnal time and sleep deprivation affect cerebrospinal fluid low-frequency oscillations and identifies wake-promoting nuclei as key drivers.

This study uses SPECT/CT to compare CSF dynamics in pigs and rats under different anesthetics, finding species- and anesthesia-specific differences in tracer distribution and clearance.

This study shows psilocybin reduces low-frequency BOLD power and alters frequency-specific connectivity in the brain.

This study quantifies inter-individual variability in PET-estimated receptor and transporter density across 12 neurotransmitter systems in the human brain.

This paper demonstrates that pretargeted PET imaging of CNS targets using monoclonal antibodies is feasible, achieving specific binding to Aβ-bound antibodies.

This study evaluates the safety, dosimetry, and pharmacokinetics of 7-[18F]Fluorotryptophan as a PET tracer for visualizing serotonin synthesis in the brain.

The paper shows that estimating correlations across brain regions from separate cohorts can be misleading due to biases and errors in interpretation.

The paper introduces a standardized nomenclature for PET-based molecular connectivity and covariance to improve reproducibility and interpretation across imaging modalities and radiotracers.

This study predicts brain age using 5-HT2AR PET and MRI data, finding that combining both improves accuracy compared to using either modality alone.

This study shows that serotonin manipulations affect decision-making flexibility in rats and humans through similar computational mechanisms.

This study compares six brain age prediction software packages using MRI data, finding pyment and brainageR to be most accurate and reliable.

This study replicates a positive association between serotonin 2A receptor binding and inward facets of neuroticism using the [11C]Cimbi-36 tracer and finds no moderating effect of cortisol awakening response.

This paper develops kinetic models for PET displacement studies to estimate target occupancy from a single scan, showing good agreement with traditional methods.

Neurotransmitter receptor/transporter PET maps (19 targets, 1239 healthy participants) align with connectomes, explain MEG power, and track cognitive gradients and cortical thinning in 13 disorders.

This paper evaluates the PET radiotracer (d3)-[11C]MODAG-001 in pigs to detect α-synuclein aggregates, showing increased binding in regions with α-synuclein pre-formed fibrils and Alzheimer's homogenate.

The paper introduces PET-BIDS, an extension of the BIDS standard for PET data, and provides curated datasets and tools for its use.

The paper develops a pig model for testing PET radioligands targeting cerebral protein aggregates, validated using [11C]PIB uptake in injected regions.

This study compares [11C]UCB-J and [18F]FDG PET in a 6-OHDA rat model of Parkinson's disease, finding divergent changes in synaptic density and metabolic function in CSTC circuits.

This study shows that psilocin levels and subjective drug intensity correlate with changes in brain network integrity and segregation after psilocybin administration.

This study examines changes in resting-state functional connectivity after a single psilocybin dose in healthy individuals, finding decreased executive control network connectivity at one-week and a link to increased mindfulness at three-months.

The paper creates a high-resolution in vivo atlas of benzodiazepine receptor densities in the human brain using PET and autoradiography data, linking it to GABAAR subunit mRNA expression.

This study links an AQP4 haplotype to variations in NREM slow wave energy and cognitive performance during wakefulness in humans.

Sleep deprivation rapidly increases serotonin 2A receptor expression in the mouse frontal cortex through the immediate early gene Egr3.

This study tests automated pupillometry with mental arithmetic to detect command following in neurological patients, finding it effective in healthy volunteers and some patients.