Pml loss worsens NEK1-linked ALS and Pml induction drives NEK1 degradation, precluding disease onset
Παναγιώτα Γεωργιάδου, Bahriye Erkaya, Michiko Niwa‐Kawakita, Merve Oltan, Yigit Kemal Keskin, Egemen Şahin, Harun Öztürk, Fatmanur Tiryaki, Kutay Yildiz, İdil Özgenç, Ezgi Odabasi, Emre Pekbilir, Şükrü Anıl Doğan, Valérie Lallemand-Breitenbach, Stephanie Vargas Aguilar, , Umut Şahin
This study shows that Pml loss worsens NEK1-linked ALS, while Pml induction reduces disease symptoms by clearing Nek1t aggregates.
FEBS Journal · Mar 10, 2026Peer-reviewedPathology