Author

Michiko Niwa‐Kawakita

Centre National de la Recherche ScientifiqueORCID 0000-0002-9450-583XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Hugues de ThéiD· 2 shared Alain ProchiantziD· 1 shared Bahriye Erkaya· 1 shared Cécile EsnaultiD· 1 shared Egemen ŞahiniD· 1 shared Elif Nur Firat‐KaralariD· 1 shared Emmanuel LaplantineiD· 1 shared Emre PekbiliriD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPathology

Hugues de ThéORCID

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2 papers

Recent·Most cited

Pml loss worsens NEK1-linked ALS and Pml induction drives NEK1 degradation, precluding disease onset

Παναγιώτα Γεωργιάδου, Bahriye Erkaya, Michiko Niwa‐Kawakita, Merve Oltan, Yigit Kemal Keskin, Egemen Şahin, Harun Öztürk, Fatmanur Tiryaki, Kutay Yildiz, İdil Özgenç, Ezgi Odabasi, Emre Pekbilir, Şükrü Anıl Doğan, Valérie Lallemand-Breitenbach, Stephanie Vargas Aguilar, , Umut Şahin

This study shows that Pml loss worsens NEK1-linked ALS, while Pml induction reduces disease symptoms by clearing Nek1t aggregates.

FEBS Journal · Mar 10, 2026Peer-reviewedPathology

PML-driven sumoylation of PML/RARA-bound co-repressors drives immortalization of primary hematopoietic progenitors

Hsin-Chieh Wu, Emmanuel Laplantine, Cécile Esnault, Michiko Niwa‐Kawakita, Yi Zhang, Marie‐Claude Geoffroy, Hugues de Thé

The paper shows that PML/RARA fusion promotes hematopoietic progenitor immortalization via PML-driven sumoylation of NCoR, enhancing transcriptional repression and contributing to APL pathogenesis.

bioRxiv · Jan 5, 2026 · PreprintCancer Biology