Author

Lee B. Smith

MRC Centre for Reproductive HealthORCID 0000-0002-4103-3074Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Developmental Biology· 2 Molecular Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Emmanouil T. DermitzakisiD· 2 shared Isabelle StévantiD· 2 shared Serge NefiD· 2 shared Yasmine NeirijnckiD· 2 shared Alessandra Livigni· 1 shared Anders JuuliD· 1 shared Annalucia L. DarbeyiD· 1 shared Anne JørgenseniD· 1 shared

Activity by Year

2016-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersDevelopmental Biology

Emmanouil T. DermitzakisORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications

Ida Marie Boisen, Nadia Krarup Knudsen, John E. Nielsen, Ireen Kooij, Mathilde Louise Bagger, Jovanna Kaludjerovic, Peter J. O’Shaughnessy, Peter W. Andrews, Noriko Ide, Birgitte Grønkær Toft, Anders Juul, Arnela Mehmedbašić, Anne Jørgensen, Lee B. Smith, Richard Norman, , Martin Blomberg Jensen

The paper shows that local mineral homeostasis changes lead to testicular microcalcifications, associated with both benign and malignant conditions.

eLife · Apr 25, 2025Peer-reviewedMolecular Biology

Specific transcriptomic signatures and dual regulation of steroidogenesis between fetal and adult mouse Leydig cells

Pauline Sararols, Isabelle Stévant, Yasmine Neirijnck, Diane Rebourcet, Annalucia L. Darbey, Michael K. Curley, Françoise Kühne, Emmanouil T. Dermitzakis, Lee B. Smith, Serge Nef

The paper compares transcriptomes of fetal and adult Leydig cells in mice to identify gene expression differences and regulatory mechanisms of steroidogenesis.

Frontiers in Cell and Developmental Biology · Jun 28, 2021Peer-reviewedDevelopmental Biology

Deciphering cell lineage specification during male sex determination with single-cell RNA sequencing

Isabelle Stévant, Yasmine Neirijnck, Christelle Borel, Jessica Escoffier, Lee B. Smith, Stylianos E. Antonarakis, Emmanouil T. Dermitzakis, Serge Nef

Time-course single-cell RNA-seq of NR5A1-GFP+ mouse XY gonad cells points to one multipotent somatic progenitor pool that yields Sertoli cells and, progressively, steroidogenic Leydig precursors.

Cell Reports · Feb 1, 2018Peer-reviewedDevelopmental Biology✦ In-depth digest

Petri Net-Based Graphical and Computational Modelling of Biological Systems

Alessandra Livigni, Laura O’Hara, Marta E. Polak, Tim Angus, Lee B. Smith, Tom C. Freeman

The paper presents a methodology for constructing biological pathway models from literature using a graphical system and simulating their dynamics.

bioRxiv · Jun 22, 2016 · PreprintSystems Biology