Isabelle Stévant

This study identifies TRIM28's role in preserving ovarian identity by stabilizing lineage-specific transcription factor hubs rather than through H3K9me3-dependent heterochromatin.

The paper constructs a comparative regulatory atlas of gonad development using mouse and human data, identifies a conserved enhancer critical for gonadal development, and prioritizes non-coding variants in DSD patients.

This study identifies how epithelial morphogens guide stepwise mesodermal specification to generate muscle diversity in Drosophila leg development.

This study shows that Enh13 is required for initiating male development but not for maintaining Sox9 expression and male fertility in differentiated testes.

The paper identifies key transcription factors and regulatory elements involved in mouse gonadal sex determination through integrated transcriptomic and chromatin accessibility analyses.

Spatial-scERA reconstructs spatial single-cell enhancer activity in multicellular organisms using integrated transcriptomic and spatial data.

This study identifies time- and sex-specific transposable element expression and epigenetic signatures in mouse fetal gonads, suggesting their role in regulating sex-specific gene expression.

The paper identifies Collagen XV-B and Tenascin C as ECM components guiding motor axon growth through their dual topology and stiffness in zebrafish.

This paper describes in-vitro protocols to differentiate mouse and human pluripotent cells into gonadal progenitors, revealing their functional equivalence to in-vivo cells and modeling DSDs.

The paper identifies and characterizes a previously uncharacterized supporting-like cell lineage in developing mouse gonads, showing its origin, specification, and sex-specific differentiation.

The paper compares transcriptomes of fetal and adult Leydig cells in mice to identify gene expression differences and regulatory mechanisms of steroidogenesis.

The paper uses single-cell RNA sequencing to study gene expression dynamics in mouse germ cells during sex determination, identifying sex-specific regulatory patterns and meiotic gene regulation.

This study identifies Wnt5a as a marker for steroidogenic progenitors that give rise to fetal and adult Leydig cells and peritubular myoid cells in the mouse testis.

The paper uses single-cell RNA sequencing to study sex determination in mouse gonadal somatic cells, identifying early progenitors and sex-specific fate acquisition in different cell lineages.

Time-course single-cell RNA-seq of NR5A1-GFP+ mouse XY gonad cells points to one multipotent somatic progenitor pool that yields Sertoli cells and, progressively, steroidogenic Leydig precursors.

The paper identifies chromosomal binding targets of SETMAR isoforms in colorectal cell lines and finds isoform-specific binding to Hsmar1 ends and non-conserved sites, with differing expression profiles between cell lines and tissues.