Author

Annalucia L. Darbey

National Hospital for Neurology and NeurosurgeryORCID 0000-0001-8541-5472Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Developmental Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Pietro FrattaiD· 2 shared Anna‐Leigh BrowniD· 1 shared Charlotte SpiceriD· 1 shared Claire E. Le PichoniD· 1 shared David ThompsoniD· 1 shared Diane RebourcetiD· 1 shared Elizabeth FisheriD· 1 shared Emmanouil T. DermitzakisiD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBioengineering

Pietro FrattaORCID

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3 papers

Recent·Most cited

BioengineeringBMC Research NotesPeer-reviewedOct 2, 2026

Refining gene delivery to skeletal muscle with a dual-strategy approach of muscle-tropic AAV capsids and muscle-specific promoters.

Annalucia L. Darbey, Wenanlan Jin, Charlotte Spicer…·Pietro Fratta

The paper investigates a dual-strategy approach using a muscle-tropic AAV capsid and muscle-specific promoter to improve gene delivery efficiency and reduce off-target expression in skeletal muscle.

DOI 10.1186/s13104-026-07998-x

mouseexperimental assay

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Molecular BiologySciencePeer-reviewedOct 3, 2024

Creation of de novo cryptic splicing for ALS/FTD precision medicine

Oscar G. Wilkins, Max Z. Y. J. Chien, Josette J Wlaschin…·Pietro Fratta

The paper develops TDP-REG, a system using cryptic splicing to enable precise gene therapy activation in diseased neurons for ALS/FTD.

39 citationstop 1%

humandeep learning

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Developmental BiologyFrontiers in Cell and Developmental BiologyPeer-reviewedJun 28, 2021

Specific transcriptomic signatures and dual regulation of steroidogenesis between fetal and adult mouse Leydig cells

Pauline Sararols, Isabelle Stévant, Yasmine Neirijnck…·Serge Nef

The paper compares transcriptomes of fetal and adult Leydig cells in mice to identify gene expression differences and regulatory mechanisms of steroidogenesis.

56 citationstop 2%

mousebulk RNA-seq

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