Yasmine Neirijnck

NEDD4 promotes Sertoli cell proliferation and adult Leydig cell differentiation in the murine testis

This study identifies NEDD4's role in promoting Sertoli cell proliferation and adult Leydig cell differentiation in murine testis development through PI3K-AKT signaling and steroidogenesis.

In vitro differentiation of mouse pluripotent stem cells into glucocorticoid-producing adrenocortical cells

This study develops a step-wise in vitro differentiation system from mouse embryonic stem cells into glucocorticoid-producing adrenocortical cells using fibronectin and cAMP activators.

Single-cell transcriptomic profiling redefines the origin and specification of early adrenogonadal progenitors

This study uses single-cell transcriptomics to redefine the origin and specification of early adrenogonadal progenitors in mice, showing distinct molecular signatures for adrenal and gonadal fates.

Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse

This study identifies bi-allelic CCDC146 mutations as a cause of non-syndromic male infertility in humans and mice, showing its role in sperm flagellum structure and microtubule organization.

TRIM28-dependent SUMOylation protects the adult ovary from the testicular pathway

This study identifies TRIM28's role in preventing female-to-male sex reversal in the adult mouse ovary by maintaining the ovarian pathway through SUMOylation.

Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad

The paper identifies and characterizes a previously uncharacterized supporting-like cell lineage in developing mouse gonads, showing its origin, specification, and sex-specific differentiation.

Oligogenic heterozygous inheritance of sperm abnormalities in mouse

The paper investigates oligogenic inheritance of sperm abnormalities in mice, finding that increasing numbers of heterozygous mutations worsen sperm morphology and motility.

Specific transcriptomic signatures and dual regulation of steroidogenesis between fetal and adult mouse Leydig cells

The paper compares transcriptomes of fetal and adult Leydig cells in mice to identify gene expression differences and regulatory mechanisms of steroidogenesis.

Single cell transcriptomics reveal temporal dynamics of critical regulators of germ cell fate during mouse sex determination

The paper uses single-cell RNA sequencing to study gene expression dynamics in mouse germ cells during sex determination, identifying sex-specific regulatory patterns and meiotic gene regulation.

Deciphering cell lineage specification during male sex determination with single-cell RNA sequencing

Time-course single-cell RNA-seq of NR5A1-GFP+ mouse XY gonad cells points to one multipotent somatic progenitor pool that yields Sertoli cells and, progressively, steroidogenic Leydig precursors.