Lipin Loo

The paper shows how SARS-CoV-2 variants, particularly Omicron, evolved proteolytic controls at the Spike furin cleavage site to enhance transmission while reducing lower respiratory tract pathogenicity.

The paper demonstrates that intranasal delivery of BDNF mRNA improves memory in aged and Alzheimer's mouse models.

This study demonstrates that intranasal mRNA-LNP delivery of synthetic oxytocin promotes social behavior and reduces pain without systemic inflammation or motor impairment.

This study identifies PRDM9 as a factor promoting survival of drug-tolerant persister cells in glioblastoma through metabolic rewiring and cholesterol biosynthesis.

This paper shows that SARS-CoV-2 Omicron lineages replicate using a specific ACE2 pool that does not complex with TMPRSS2, unlike pre-Omicron variants.

The paper identifies differences in stress response and function between macular and peripheral Muller cells, linking these differences to vulnerability to degenerative diseases.

The paper characterizes cell-cell communication patterns in COVID-19 patients to identify differences between moderate and severe disease outcomes using single-cell RNA-seq data.

This study creates a single-cell transcriptomic catalog of mouse cortical development, revealing cell types, states, and their relationships, and linking gene expression to disease subtypes.