Parl Deficiency In Mouse Causes Coenzyme Q Depletion, Complex III Defects, And Leigh-Like Syndrome
Marco Spinazzi, Enrico Radaelli, Katrien Horré, Amaia M. Arranz, Natalia V. Gounko, Patrizia Agostinis, Teresa Mendes Maia, Francis Impens, Vanessa A. Morais, Guillermo López‐Lluch, Lutgarde Serneels, Plácido Navas, Bart De Strooper
This study shows that Parl deficiency in mice leads to mitochondrial dysfunction, Complex III defects, and Leigh-like syndrome, highlighting its critical role in neurological health.
Proceedings of the National Academy of Sciences · Dec 21, 2018Peer-reviewedMolecular Biology