Amaia M. Arranz

This study shows that APOE3 and APOE4 human astrocytes differentially affect Alzheimer's disease hallmarks in chimeric mice, with APOE3 reducing and APOE4 worsening pathology.

The paper shows that MEG3, a long noncoding RNA, induces necroptosis in human neurons exposed to amyloid pathology, mimicking AD features in a xenograft model.

The paper transplants human iPSC-derived astrocytes into mouse brains to study their response to amyloid-β plaques, finding morphological changes independent of APOE alleles.

The paper demonstrates that human microglia derived from embryonic stem cells can engraft mouse brains and express Alzheimer's risk genes when exposed to Aβ, offering a new model to study genetic risk in AD.

This study shows that Parl deficiency in mice leads to mitochondrial dysfunction, Complex III defects, and Leigh-like syndrome, highlighting its critical role in neurological health.