Lutgarde Serneels

The Alzheimer's therapeutic Lecanemab induces an amyloid-clearing program in microglia

This study shows Lecanemab reduces amyloid pathology by activating microglia through Fc fragment engagement, enhancing phagocytosis and lysosomal degradation.

A versatile mouse model to advance human microglia transplantation research in neurodegenerative diseases

The paper develops a new mouse model for human microglia transplantation to study neurodegenerative diseases and makes it publicly available.

Microglia initially seed and later reshape amyloid plaques in Alzheimer's disease

This study shows microglia initially seed amyloid plaques in Alzheimer's disease but later help compact them, with genetic and pharmacological manipulation affecting plaque formation.

A multi-pronged human microglia response to Alzheimer's disease Aβ pathology

This study identifies distinct microglial responses to amyloid-beta in AD using single-cell data, highlighting HLA-related and cytokine responses and their genetic modulation.

Functional and topological analysis of PSENEN, the fourth subunit of the gamma-secretase complex

This study investigates the role of PSENEN in the gamma-secretase complex, showing its structural and functional importance in complex formation and cleavage activity.

Long noncoding RNA MEG3 activates neuronal necroptosis in Alzheimer's disease

The paper shows that MEG3, a long noncoding RNA, induces necroptosis in human neurons exposed to amyloid pathology, mimicking AD features in a xenograft model.

The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research

This study shows that the AppNL-G-F mouse retina accumulates Aβ early and exhibits AD-like features, suggesting it as a model for preclinical AD research and diagnosis.

Stem cell derived human microglia transplanted in mouse brain to study genetic risk of Alzheimer's Disease

The paper demonstrates that human microglia derived from embryonic stem cells can engraft mouse brains and express Alzheimer's risk genes when exposed to Aβ, offering a new model to study genetic risk in AD.

Parl Deficiency In Mouse Causes Coenzyme Q Depletion, Complex III Defects, And Leigh-Like Syndrome

This study shows that Parl deficiency in mice leads to mitochondrial dysfunction, Complex III defects, and Leigh-like syndrome, highlighting its critical role in neurological health.