Macropinocytosis mediates resistance to loss of glutamine transport in triple-negative breast cancer
Kanu Wahi, Natasha Freidman, Qian Wang, Michelle Devadason, Lake‐Ee Quek, Angel Pang, Larissa Lloyd, Mark Larance, Fabio Zanini, Kate Harvey, Sandra A O'Toole, Yi Fang Guan, Jeff Holst
The paper shows that TNBC cells compensate for loss of ASCT2 glutamine uptake by increasing macropinocytosis, suggesting resistance to targeting glutamine transport alone.
The EMBO Journal · Oct 17, 2024Peer-reviewedCancer Biology