Sandra A O'Toole

SIMPlex generates matched spatial and single-nucleus transcriptomic profiles from the same tissue section to resolve cell states with spatial signatures in mouse and human cancer tissues.

This paper shows that ROCK2 inhibition reduces ECM remodelling and cell growth while impairing migration and invasion in breast cancer models.

The paper identifies a selective JNK inhibitor that blocks metastasis in triple-negative breast cancer by targeting metabolic pathways.

The paper shows that TNBC cells compensate for loss of ASCT2 glutamine uptake by increasing macropinocytosis, suggesting resistance to targeting glutamine transport alone.

This study introduces a method to generate high-quality single-nucleus transcriptomic data from FFPE samples using recent single-cell genomic technology.