Jeff Holst

The paper identifies a selective JNK inhibitor that blocks metastasis in triple-negative breast cancer by targeting metabolic pathways.

The paper shows that TNBC cells compensate for loss of ASCT2 glutamine uptake by increasing macropinocytosis, suggesting resistance to targeting glutamine transport alone.

AAnet identifies archetypal cell states in single-cell data to reveal tumor heterogeneity and spatial organization.

HyperSeq integrates hyperspectral imaging and transcriptomics on the same cell to link optical spectra with molecular states in MCF-7 breast cancer cells.

This study shows that SLC7A11 in pancreatic ductal adenocarcinoma stroma, not tumor cells, predicts poor survival and that inhibiting it reduces CAF activity and tumor growth.