Shu Ye

This study identifies genetic determinants of endothelial cell molecular traits and their overlap with disease GWAS loci, revealing shared and unique mechanisms in non-communicable diseases.

The paper identifies and validates novel regulators of vascular smooth muscle cell proliferation using network analysis and experimental validation, highlighting RUNX1 and the TIMP1-CD74 axis as potential therapeutic targets.

This study shows that the coronary artery disease variant rs17514846 affects FURIN expression through allele-specific DNA methylation and MeCP2 binding in monocytes.

The paper identifies and characterizes 329 novel long non-coding RNAs in vascular smooth muscle cells, finding they are mostly antisense transcripts with cytoplasmic localization and miRNA targets.

This paper develops a genomic risk score for coronary artery disease using 1.7 million variants and tests it in UK Biobank, showing it outperforms conventional risk factors in predicting CAD risk.