This study identifies genetic determinants of endothelial cell molecular traits and their overlap with disease GWAS loci, revealing shared and unique mechanisms in non-communicable diseases.

bioRxiv · Nov 10, 2025 · PreprintGenomics

Network-based prioritisation and validation of novel regulators of vascular smooth muscle cell proliferation in disease

Jordi Lambert, Sebnem Oc, Matthew D. Worssam, Daniel Häußler, Charles Ugochukwu Solomon, Nichola L. Figg, Ruby M. Baxter, Maria Imaz, James C K Taylor, Kirsty Foote, Alison J. Finigan, Krishnaa T. A. Mahbubani, Tom R. Webb, Shu Ye, Martin R. Bennett, , Helle Færk Jørgensen

The paper identifies and validates novel regulators of vascular smooth muscle cell proliferation using network analysis and experimental validation, highlighting RUNX1 and the TIMP1-CD74 axis as potential therapeutic targets.

Nature Cardiovascular Research · Jun 6, 2024Peer-reviewedMolecular Biology

Identification and Characterization of novel long non-coding RNAs in vascular smooth cells

Charles Ugochukwu Solomon, David G. McVey, Catherine Andreadi, Peng Gong, Lanka Turner, Sonja Khemiri, Julie C. Chamberlain, Tom R. Webb, Nilesh J. Samani, Shu Ye

The paper identifies and characterizes 329 novel long non-coding RNAs in vascular smooth muscle cells, finding they are mostly antisense transcripts with cytoplasmic localization and miRNA targets.

bioRxiv · Jan 6, 2023 · PreprintBioinformatics