Circuit to target approach defines an autocrine myofibroblast loop that drives cardiac fibrosis
Shoval Miyara, Miri Adler, Kfir Baruch Umansky, Daniel Häußler, Elad Bassat, Yalin Divinsky, Jacob Elkahal, David Kain, Daria Lendengolts, Ricardo O. Ramirez Flores, Hanna Bueno-Levy, Ofra Golani, Tali Shalit, Michael Gershovits, Eviatar Weizman, , Eldad Tzahor
The paper models a macrophage-myofibroblast circuit to predict fibrosis types and shows targeting the myofibroblast autocrine loop reduces fibrosis after myocardial infarction.
Cell Systems · Feb 18, 2025Peer-reviewedSystems Biology