This study performs genome-wide association analysis on composite sleep health scores, identifying 28 novel loci and confirming 341 previously reported loci, with insights into genetic mechanisms and pathways.

Communications Biology · Jan 24, 2025Peer-reviewedGenetic & Genomic Medicine

Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

Heming Wang, Jacqueline M. Lane, Samuel E. Jones, Hassan S. Dashti, Hanna Maria Ollila, Andrew R. Wood, Vincent T. van Hees, Ben Michael Brumpton, Bendik Slagsvold Winsvold, Katri Kantojärvi, Teemu Palviainen, Brian E. Cade, Tamar Sofer, Yanwei Song, Krunal Patel, , Richa Saxena

This study identifies 42 genetic loci associated with excessive daytime sleepiness and links them to phenotypic subgroups and related traits.

Nature Communications · Aug 13, 2019Peer-reviewedGenomics

GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

Hassan S. Dashti, Samuel E. Jones, Andrew R. Wood, Jacqueline M. Lane, Vincent T. van Hees, Heming Wang, Jessica A. Rhodes, Yanwei Song, Krunal Patel, Simon George Anderson, Robin N. Beaumont, David A. Bechtold, Jack Bowden, Brian E. Cade, Marta Garaulet, , Richa Saxena

Nature Communications · Mar 7, 2019Peer-reviewedGenetics

Biological and clinical insights from genetics of insomnia symptoms

HUNT All In Sleep, Jacqueline M. Lane, Samuel E. Jones, Hassan S. Dashti, Andrew R. Wood, Krishna G. Aragam, Vincent T. van Hees, Linn Beate Strand, Bendik Slagsvold Winsvold, Heming Wang, Jack Bowden, Yanwei Song, Krunal Patel, Simon George Anderson, Robin N. Beaumont, , Richa Saxena

The paper identifies 57 genomic regions associated with insomnia symptoms, linking them to phototransduction, ubiquitination, and potential causal relationships with coronary heart disease and depression.

Nature Genetics · Feb 25, 2019Peer-reviewedGenomics