Simon David Kyle

Discovering the genetic architecture of sleep regulation: genome-wide association study of device-measured sleep traits.

This study identifies 20 genetic loci associated with sleep traits using UK Biobank data, including novel signals for REM and NREM sleep duration and sex-specific associations.

Genome-wide association analysis of composite sleep health scores in 413,904 individuals

This study performs genome-wide association analysis on composite sleep health scores, identifying 28 novel loci and confirming 341 previously reported loci, with insights into genetic mechanisms and pathways.

The effect of sleep continuity disruption on multimodal emotion processing and regulation: a laboratory-based, randomized, controlled experiment in good sleepers

This study disrupts sleep continuity in good sleepers and finds effects on memory, vigilance, and self-reported affect, but not on emotion processing or regulation tasks.

Genome-wide association analysis of excessive daytime sleepiness identifies 42 loci that suggest phenotypic subgroups

This study identifies 42 genetic loci associated with excessive daytime sleepiness and links them to phenotypic subgroups and related traits.

GWAS in 446,118 European adults identifies 78 genetic loci for self-reported habitual sleep duration supported by accelerometer-derived estimates

Biological and clinical insights from genetics of insomnia symptoms

The paper identifies 57 genomic regions associated with insomnia symptoms, linking them to phototransduction, ubiquitination, and potential causal relationships with coronary heart disease and depression.

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

This study identifies new genetic loci associated with sleep disturbance traits and finds shared genetic links with neuropsychiatric and metabolic traits.